Summary
1) Tebafen which contains thiosemicarbazone derivative and INH was administered to
the 19 lung T.B patients for 6 months.
2) Observed on its X-Ray improvement, sputun conversion rate, and on its clinical
symptomes, Its effects seem to be inferior to those of other anti-tubercalose drugs such
as INH. and PAS.
3) No Significant side reactions were obserkbed.
REFERENCE
1) The effect of Acetylaminobenzal Thiosemicarbazine of expermental Tuberculosis in
Guinea Pigs.
American Review of Tuberculosis
Aug., 1950..........David M. Spain.
2) The therapcutic effect on experimental Tuberulosis in Guinea Pigs of
4-Acetylaminobenzal Thiosemicarbazone in Combination with Dihydro S.M. as compared
with the efect of PAs in combination with Dihydro S.M.
American Review of Tuberculosis
March, 1951..........David M. Spain,
William G. Childress.
3) Thiosemicarbazone in chemotherapy of Tuberculosis.
Report by Research Comettee of Britich Tuberculosis Association. Tubercle,
October, 1951.
4) Studies in experimental Tuberculosis in Vitro and in vivo activities of
Thiosemicarbazone.
Antibiotic.
Jan., 1952..........C.J. Duca
5)Clinical trial of Paramino-Isobutoxbenzaldehyde-Thiosemicarbazone in 8 cases of
Tuberculosis.
American Review of Tuberculosis
November, 1953..........Edward M. Garment.
6) Failure of Paramino-Isobut oxybenzaldehyde-Thiosemicarbazone as an
Antituberculouse drugs in man.
American Review of Tuberculosis.
November, 1953..........Carl Muschenhein.
7) Paramino-Isobutoxybenzaldehyde-Yhiosemicarbazone in the Treatment of Pulmonary
Tuberculosis.
American Review of Tuberculosis.
November, 1953..........William R. Barclary.
8) Paramino-Isobutoxybenzaldehyde-Thiosimicarbazone in Pulmonary Tuberculosis.
American Review of Tuberculosis.
American Review of Tuberculosis.
November, 1953..........Edward. M. Garment.
9) Preliminary experience in the Treatment of Tuberculosis with combined Preparation
Nicoteben.
American Review of Tuberculosis.
Jan., 1958..........Abstract P-18.
10) Applied Pharmecology
A. J. Clark
11) Pharmecology in Clinical Practice.
Harry Beckman.
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